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The Journal of Heredity 2001:92(6)
© 2001 The American Genetic Association 92:516-519

Brief Communication

A Radiation Hybrid Mapping Panel for the Rhesus Macaque

W. J. Murphy, J. E. Page, C. Smith, Jr., R. C. Desrosiers, and S. J. O'Brien

From the Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702 (Murphy, Page, Smith, and O'Brien) and the New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772 (Desrosiers).

Address correspondence to William Murphy, Laboratory of Genomic Diversity, Bldg. 560, Rm. 11–10, National Cancer Institute–FCRCD, Frederick, MD 21702, or e-mail: murphywi@mail.ncifcrf.gov.

The genomes of nonhuman primates have recently become highly visible candidates for full genome analysis, as they provide powerful models of human disease and a better understanding of the evolution of the human genome. We describe the creation of a 5000 rad radiation hybrid (RH) mapping panel for the rhesus macaque. Duplicate genotypes of 84 microsatellite and coding gene sequence tagged sites from six macaque chromosomes produced an estimated whole genome retention frequency of 0.33. To test the mapping ability of the panel, we constructed RH maps for macaque chromosomes 7 and 9 and compared them to orthologous locus orders in existing human and baboon maps derived from different methodologies. Concordant marker order between all three species maps suggests that the current panel represents a powerful mapping resource for generating high-density comparative maps of the rhesus macaque and other species genomes.


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