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Journal of Heredity 2003:94(1)
© 2003 The American Genetic Association 94:49-56

Isolation and Characterization of the Canine Serotonin Receptor 1A Gene (htr1A)

L. van den Berg, S. A. Versteeg, and B. A. van Oost

From the Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 8, 3584 CM Utrecht, the Netherlands.

Address correspondence to L. van den Berg or B. van Oost at their respective addresses above, or e-mail: L.vandenBerg{at}vet.uu.nl or b.vanOost{at}vet.uu.nl.

Although the serotonergic system and htr1A have been studied extensively, little is known about the canine serotonin receptor 1A. We are interested in this receptor in the dog because it is likely to be involved in behavioral disorders such as anxiety. Therefore, we isolated a canine bacterial artificial chromosome (BAC) clone containing htr1A, and, with the help of this clone, the complete canine coding sequence of this gene was determined. Radiation hybrid (RH) mapping showed that htr1A is part of a conserved linkage group also including the survival of motor neuron 1 (smn1) gene. Htr1A is estimated to be located about 7.3 Mb from smn1 on cfa02. In addition, we report a possible breed-specific variant of the gene in four golden retrievers.


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