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Journal of Heredity 2003:94(1)
© 2003 The American Genetic Association 94:65-68

Two Cases of Infertile Bitches With 78,XX/77,X Mosaic Karyotype: A Need for Cytogenetic Evaluation of Dogs With Reproductive Disorders

M. Switonski, I. Szczerbal, J. Grewling, P. Antosik, W. Nizanski, and F. Yang

From the Department of Genetics and Animal Breeding (Switonski, Szczerbal, and Grewling) and the Department of Veterinary Agriculture (Antosik), August Cieszkowski Agricultural University of PoznÄn, Wolynska 33, 60-637 PoznÄn, Poland; the Department of Animal Reproduction, Faculty of Veterinary Medicine, Agricultural University of Wroclaw, Wroclaw, Poland (Nizanski); and the Center for Veterinary Science, Madingley Road, University of Cambridge, Cambridge, United Kingdom (Yang).

Address correspondence to Marek Switonski at the address above, or e-mail: switonsk{at}jay.au.poznan.pl.

A mosaic karyotype 78,XX/77,X was found in two infertile purebred dogs. Cytogenetic investigations were carried out on a large number of metaphase spreads (220 and 473) with the use of conventional Giemsa staining, C-banding, and chromosome painting approaches. The frequencies of the monosomic spreads (77,X) were low: 5.3% and 5.6%. We recommend that at least 90 metaphase spreads be analyzed to allow possible detection of low-level XX/X mosaicism, and we discuss the need for cytogenetic evaluation of dogs with reproductive disorders.


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