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Journal of Heredity 2003:94(1)
© 2003 The American Genetic Association 94:9-13

Comparison of MultiMap and TSP/CONCORDE for Constructing Radiation Hybrid Maps

C. Hitte, T. D. Lorentzen, R. Guyon, L. Kim, E. Cadieu, H. G. Parker, P. Quignon, J. K. Lowe, B. Gelfenbeyn, C. Andre, E. A. Ostrander, and F. Galibert

From UMR6061, CNRS, Université de Rennes1, 2 av. Pr. Léon Bernard 35043 Rennes Cedex, France (Hitte, Guyon, Cadieu, Quignon, Andre, and Galibert) and the Divisions of Clinical Research and Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N, D4-100, Seattle WA 98109-1024 (Lorentzen, Kim, Parker, Lowe, Gelfenbeyn, and Ostrander).

Address correspondence to Francis Galibert at the address above, or e-mail: francis.galibert{at}univ-rennes1.fr.

Radiation hybrid (RH) map construction allows investigators to locate both type I and type II markers on a given genome map. The process is composed of two steps. The first consists of determining the pattern distribution of a set of markers within the different cell lines of an RH panel. This is mainly done by polymerase chain reaction (PCR) amplification and gel electrophoresis, and results in a series of numbers indicating the presence or the absence of each marker in each cell line. The second step consists of a comparison of these numbers, using various algorithms, to group and then order markers. Because different algorithms may provide (slightly) different orders, we have compared the merits of the MultiMap and TSP/CONCORDE packages using a data set of information currently under analysis for construction of the canine genome RH map.


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A. A. Schaffer, E. S. Rice, W. Cook, and R. Agarwala
rh_tsp_map 3.0: end-to-end radiation hybrid mapping with improved speed and quality control
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