Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (2)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Carleos, C.
Right arrow Articles by Corral, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Carleos, C.
Right arrow Articles by Corral, N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Journal of Heredity 2003:94(2)
© 2003 The American Genetic Association 94:175-179

Brief Communication

Asymptotic Variances of QTL Estimators With Selective DNA Pooling

C. Carleos, J. A. Baro, J. Cañon, and N. Corral

From the Departamento de Estadística, Facultad de Ciencias, C/Calvo Sotelo 33007 Oviedo, Asturias, Spain (Carleos); Departamento de Ciencias Agroforestales, Universidad de Valladolid, Palencia, Spain (Baro); Departamento de Produccion Animal, Universidad Complutense, Madrid, Spain (Cañon); and Departamento de Estadistica, Universidad de Oviedo, Oviedo, Spain (Corral).

Address correspondence to Carlos Carleos at the address above, or e-mail: carleos{at}pinon.ccu.uniovi.es.

Investigation on QTL-marker linkage usually requires a great number of observed recombinations, inferred from combined analysis of phenotypes and genotypes. To avoid costly individual genotyping, inferences on QTL position and effects can instead make use of marker allele frequencies. DNA pooling of selected samples makes allele frequency estimation feasible for studies involving large sample sizes. Linkage studies in outbred populations have traditionally exploited half-sib family designs; within the animal production context, half-sibships provide large families that are highly suitable for DNA pooling. Estimators for QTL position and effect have been proposed that make use of information from flanking markers. We present formulas derived by the delta method for the asymptotic variance of these estimators.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 GeneticsHome page
A. Korol, Z. Frenkel, L. Cohen, E. Lipkin, and M. Soller
Fractioned DNA Pooling: A New Cost-Effective Strategy for Fine Mapping of Quantitative Trait Loci
Genetics, August 1, 2007; 176(4): 2611 - 2623.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.