Journal of Heredity 2003:94(6)
© 2003 The American Genetic Association 94:496-506
Mapping of QTL for Body Conformation and Behavior in Cattle
From the Institut für Tierzucht und Haustiergenetik der Justus-Liebig-Universität, D-35390 Giessen, Germany (Hiendleder, Leyhe-Horn, and Erhardt), Institut für Tierzucht und Tierhaltung der Christian-Albrechts-Universität, D-24118 Kiel, Germany (Thomsen, Reinsch, Bennewitz, Looft, Xu, and Kalm), Institut für Tierzucht der Ludwig-Maximilians-Universität, D-80539 München, Germany (Medjugorac, Russ, Förster), Forschungsinstitut für die Biologie Landwirtschaftlicher Nutztiere, Forschungsbereich Molekularbiologie, D-18196 Dummerstorf, Germany (Kühn, Brockmann, and Schwerin), Institut für die Fortpflanzung landwirtschaftlicher Nutztiere, D-16321 Schoenow, Germany (Blümel), Tierärztliches Institut der Georg-August-Universität, D-37073 Göttingen, Germany (Brenig), Vereinigte Informationssysteme Tierhaltung w.V., D-27283 Verden/Aller, Germany (Reinhardt and Reents), and Bayerische Landesanstalt für Tierzucht, D-85586 Grub, Germany (Averdunk).
Address correspondence to Stefan Hiendleder, Department of Molecular Animal Breeding and Biotechnology, Ludwig-Maximilian University Munich, Hackerstraße 27, D-85764 Oberschleißheim, Germany, or email: S.Hiendleder{at}gen.vetmed.uni-muenchen.de.
Genome scans for quantitative trait loci (QTL) in farm animals have concentrated on primary production and health traits, and information on QTL for other important traits is rare. We performed a whole genome scan in a granddaughter design to detect QTL affecting body conformation and behavior in dairy cattle. The analysis included 16 paternal half-sib families of the Holstein breed with 872 sons and 264 genetic markers. The markers were distributed across all 29 autosomes and the pseudoautosomal region of the sex chromosomes with average intervals of 13.9 cM and covering an estimated 3155.5 cM. All families were analyzed jointly for 22 traits using multimarker regression and significance thresholds determined empirically by permutation. QTL that exceeded the experiment-wise significance threshold (5% level) were detected on chromosome 6 for foot angle, teat placement, and udder depth, and on chromosome 29 for temperament. QTL approaching experiment-wise significance (10% level) were located on chromosome 6 for general quality of feet and legs and general quality of udder, on chromosome 13 for teat length, on chromosome 23 for general quality of feet and legs, and on chromosome 29 for milking speed. An additional 51 QTL significant at the 5% chromosome-wise level were distributed over 21 chromosomes. This study provides the first evidence for QTL involved in behavior of dairy cattle and identifies QTL for udder conformation on chromosome 6 that could form the basis of recently reported QTL for clinical mastitis.
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