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Journal of Heredity 2004:95(2):103-113
© 2004 The American Genetic Association

Comparative Genome Analysis of the Yellow Fever Mosquito Aedes aegypti with Drosophila melanogaster and the Malaria Vector Mosquito Anopheles gambiae

D. W. Severson, B. deBruyn, D. D. Lovin, S. E. Brown, D. L. Knudson, and I. Morlais

From the Center for Tropical Disease Research and Training, Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556 (Severson, deBruyn, Lovin, and Morlais); and from the Department of Bioagricultural Sciences and Pest Management, Colorado State University, Fort Collins, CO 80523 (Brown and Knudson). This work was supported by the grants AI33127 and AI34337 from the National Institutes of Health.

Address correspondence to D. W. Severson at the above address, or e-mail: David.W.Severson.1{at}nd.edu.

An in silico comparative genomics approach was used to identify putative orthologs to genetically mapped genes from the mosquito, Aedes aegypti, in the Drosophila melanogaster and Anopheles gambiae genome databases. Comparative chromosome positions of 73 D. melanogaster orthologs indicated significant deviations from a random distribution across each of the five A. aegypti chromosomal regions, suggesting that some ancestral chromosome elements have been conserved. However, the two genomes also reflect extensive reshuffling within and between chromosomal regions. Comparative chromosome positions of A. gambiae orthologs indicate unequivocally that A. aegypti chromosome regions share extensive homology to the five A. gambiae chromosome arms. Whole-arm or near-whole-arm homology was contradicted with only two genes among the 75 A. aegypti genes for which orthologs to A. gambiae were identified. The two genomes contain large conserved chromosome segments that generally correspond to break/fusion events and a reciprocal translocation with extensive paracentric inversions evident within. Only very tightly linked genes are likely to retain conserved linear orders within chromosome segments. The D. melanogaster and A. gambiae genome databases therefore offer limited potential for comparative positional gene determinations among even closely related dipterans, indicating the necessity for additional genome sequencing projects with other dipteran species.


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