Skip Navigation


Journal of Heredity Advance Access originally published online on January 27, 2005
Journal of Heredity 2005 96(3):253-260; doi:10.1093/jhered/esi031
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
96/3/253    most recent
esi031v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (7)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Real, L. A.
Right arrow Articles by Childs, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Real, L. A.
Right arrow Articles by Childs, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2005 The American Genetic Association

Spatial Dynamics and Molecular Ecology of North American Rabies

L. A. Real, C. Russell, L. Waller, D. Smith, and J. Childs

From the Department of Biology and Center for Disease Ecology, Emory University, 1510 Clifton Rd. NE, Atlanta, GA 30322 (Real and Childs); the Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, United Kingdom (Russell); the Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322 (Waller); and the Fogarty International Center, Room 309, Building 16, 16 Center Drive, Bethesda, MD 20892 (Smith)

Address correspondence to L. A. Real at the address above, or e-mail: lreal{at}emory.edu.

Rabies, caused by a single-stranded RNA virus, is arguably the most important viral zoonotic disease worldwide. Although endemic throughout many regions for millennia, rabies is also undergoing epidemic expansion, often quite rapid, among wildlife populations across regions of Europe and North America. A current rabies epizootic in North America is largely attributable to the accidental introduction of a particularly well-adapted virus variant into a naïve raccoon population along the Virginia/West Virginia border in the mid-1970s. We have used the extant database on the spatial and temporal occurrence of rabid raccoons across the eastern United States to construct predictive models of disease spread and have tied patterns of emergence to local environmental variables, genetic heterogeneity, and host specificity. Rabies will continue to be a remarkable model system for exploring basic issues in the temporal and spatial dynamics of expanding infectious diseases and examining ties between disease population ecology and evolutionary genetics at both micro- and macro-evolutionary time scales.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
R. Biek, J. C. Henderson, L. A. Waller, C. E. Rupprecht, and L. A. Real
A high-resolution genetic signature of demographic and spatial expansion in epizootic rabies virus
PNAS, May 8, 2007; 104(19): 7993 - 7998.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.