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Journal of Heredity Advance Access originally published online on October 26, 2005
Journal of Heredity 2005 96(7):766-773; doi:10.1093/jhered/esi122
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© The American Genetic Association. 2005. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Chromosome Rearrangements in Canine Fibrosarcomas

D. R. Sargan, B. S. Milne, J. Aguirre Hernandez, P. C. M. O'Brien, M. A. Ferguson-Smith, T. Hoather, and J. M. Dobson

From the Centre for Veterinary Science, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK

Address correspondence to David R. Sargan at the address above, or e-mail: drs20{at}cam.ac.uk.

We have previously reported the use of six- and seven-color paint sets in the analysis of canine soft tissue sarcomas. Here we combine this technique with flow sorting of translocation chromosomes, reverse painting, and polymerase chain reaction (PCR) analysis of the gene content of the reverse paint in order to provide a more detailed analysis of cytogenetic abnormalities in canine tumors. We examine two fibrosarcomas, both from female Labrador retrievers, and show abnormalities in chromosomes 11 and 30 in both cases. Evidence of involvement of TGFBR1 is presented for one tumor.


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