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Journal of Heredity Advance Access originally published online on February 17, 2006
Journal of Heredity 2006 97(2):186-190; doi:10.1093/jhered/esj022
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© The American Genetic Association. 2006. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Brief Communication

Primate MicroRNAs miR-220 and miR-492 Lie within Processed Pseudogenes

Eric J. Devor

From Molecular Genetics and Bioinformatics, Integrated DNA Technologies, 1710 Commercial Park, Coralville, IA 52241

Address correspondence to E. J. Devor at the address above, or e-mail: rdevor{at}idtdna.com.

MicroRNAs (miRNAs) are a new and abundant class of small, noncoding RNAs. To date, the evolutionary history of most of these loci appears to be marked by duplication and divergence. The ultimate origin of miRNAs remains an open question. A survey of the genomic context of more than 300 human miRNA loci revealed that two primate-specific miRNAs, miR-220 and miR-492, each lie within a processed pseudogene. In silico and in vitro examinations of these two loci suggest that this is a rare phenomenon requiring the juxtaposition of a specific combination of factors. Thus it appears that, while processed pseudogenes are good candidates for miRNA incubators, it is unlikely that more than a very small percentage of new miRNAs arise this way.


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