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Journal of Heredity Advance Access originally published online on June 22, 2006
Journal of Heredity 2006 97(4):355-366; doi:10.1093/jhered/esl009
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© The American Genetic Association. 2006. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

A Quantitative Trait Locus Analysis of Natural Genetic Variation for Drosophila melanogaster Oxidative Stress Survival

Yue Wang, David Pot, Stephen D. Kachman, Sergey V. Nuzhdin, and Lawrence G. Harshman

From the Department of Statistics, University of Nebraska–Lincoln, Lincoln, NE 68583-0963 (Wang and Kachman); CIRAD, UMR PIA 1096, Avenue Agropolis, 34398 Montpellier Cedex 5, France (Pot); the Section of Evolution and Ecology, University of California at Davis, Davis, CA 95616 (Nuzhdin); and the School of Biological Sciences, University of Nebraska–Lincoln, Lincoln, NE 68588-0118 (Harshman)

Address correspondence to L. G. Harshman at the address above, or e-mail: lharsh{at}unlserve.unl.edu.

Little is known about natural genetic variation for survival under oxidative stress conditions or whether genetic variation for oxidative stress survival is associated with that for life-history traits. We have investigated survival in a high-oxygen environment at 2 adult densities using a set of recombinant inbred lines (RILs) isolated from a natural population of Drosophila melanogaster. Female and male oxidative stress survival was highly correlated. Quantitative trait loci (QTLs) for oxidative stress survival were identified on both autosomes. These QTLs were sometimes sex or density specific but were most often not. QTLs were identified that colocalize to the same region of the genome as longevity in other studies using the same set of RILs. We also determined early-age egg production and found QTLs for this trait, but there was no support for an association between oxidative stress survival and egg production.


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