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Journal of Heredity Advance Access published online on May 22, 2008
Journal of Heredity, doi:10.1093/jhered/esn029
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© The American Genetic Association. 2008. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Concerted Evolution of Vertebrate CCR2 and CCR5 Genes and the Origin of a Recombinant Equine CCR5/2 Gene

Andrey A. Perelygin, Andrey A. Zharkikh, Natalia M. Astakhova, Teri L. Lear, and Margo A. Brinton

From the Department of Biology, Georgia State University, PO Box 4010, Atlanta, GA 30302 (Perelygin, Astakhova, and Brinton); the Bioinformatics Department, Myriad Genetics, Inc., Salt Lake City, 320 Wakara Way, UT 84108 (Zharkikh); and the Department of Veterinary Science, University of Kentucky, 108 Maxwell H. Gluck Equine Research Center, Lexington, KY 40546 (Lear)

Address correspondence to Andrey A. Perelygin at the address above, or e-mail: aperelygin{at}gsu.edu.

Chemokine receptors (CCRs) play an essential role in the initiation of an innate immune host response. Several of these receptors have been shown to modulate the outcome of viral infections. The recent availability of complete genome sequences from a number of species provides a unique opportunity to analyze the evolution of the CCR genes. A phylogenetic analysis revealed that the CCR2 gene evolved in concert with the paralogous CCR5 gene, but not with another paralogous gene, CCR3, in the opossum, platypus, rabbit, guinea pig, cat, and rodent lineages. In addition, evidence of concerted evolution of the CCR2 and CCR5 genes was observed in chicken and lizard genomes. A unique CCR5/2 gene that originated by unequal crossing over between the CCR2 and CCR5 genes was detected in the domestic horse. The CCR2, CCR5, and CCR5/2 genes were mapped to ECA16q21 using fluorescent in situ hybridization (FISH). Single-nucleotide polymorphisms identified in the equine CCR5 gene and characterized within 5 horse breeds provide haplotype markers for future case/control studies investigating the genetic bases of horse susceptibility to infectious diseases.

Corresponding Editor: Ernest Bailey

Received October 26, 2007
Accepted April 10, 2008


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