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Journal of Heredity Advance Access originally published online on July 16, 2009
Journal of Heredity 2009 100(6):742-753; doi:10.1093/jhered/esp043
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© The American Genetic Association. 2009. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Original Articles

Evolution of the GST Omega Gene Family in 12 Drosophila Species

Kathryn B. Walters, Paaqua Grant, and Diana L. E. Johnson

Department of Biological Sciences, The George Washington University, Washington, DC 20052

Address correspondence to Diana L. E. Johnson, Department of Biological Sciences, Lisner Hall Room 340, The George Washington University, Washington, DC 20052, or e-mail: dejohnsn{at}gwu.edu.

Gene families provide a unique system to study the evolutionary relationships between related genes both within and between organisms. We can ascertain whether members of a gene family in different species are orthologs or paralogs. We may also search for evidence that may explain why duplicate genes are present. The availability of genome sequences for 12 Drosophila species allows us to address these questions with respect to the evolution of one gene family, the glutathione S transferase (GST) omega class. This gene family is of particular interest because of its relationship with human disease and its presence in a wide range of species.

Key Words: gene families • glutathione S transferase omega • positive selection

Corresponding Editor: Ross MacIntyre

Received May 21, 2008
Revised April 3, 2009
Accepted June 5, 2009


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