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Journal of Heredity Advance Access published online on November 19, 2009
Journal of Heredity, doi:10.1093/jhered/esp100
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© The American Genetic Association. 2009. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Association Study of Cobalamin Deficiency in the Chinese Shar Pei

Niels Grützner, Micah A. Bishop, Jan S. Suchodolski, and Jörg M. Steiner

From the Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4474

Address correspondence to N. Grützner at the address above, or e-mail: ngruetzner{at}cvm.tamu.edu.

Cobalamin deficiency is a common disorder in Chinese Shar Peis (Shar Peis) and is thus suspected to be hereditary. The objective of this study was to identify a genomic region or locus that cosegregates with the phenotype of cobalamin deficiency in Shar Peis. Serum cobalamin concentrations were measured, and blood for genomic DNA extraction was collected from 14 cobalamin-deficient Shar Peis and 28 Shar Peis with a serum cobalamin concentration in the reference range. The 327 microsatellite markers from the canine minimal screening set 2 and 4 additional markers were amplified by polymerase chain reaction and genotyped by automated capillary electrophoresis. Two microsatellite markers, DTR13.6 (P = 1.4 x 10–6) and REN13N11 (P = 1.5 x 10–5), both on canine chromosome 13, showed evidence of linkage disequilibrium. These findings indicate that the region of chromosome 13 near these markers should be mapped and closely examined for potential mutations associated with this disease in Shar Peis.

Key Words: Chinese Shar Peis • cobalamin • linkage • microsatellite

Corresponding Editor: Elaine Ostrander

Received March 11, 2009
Revised September 22, 2009
Accepted October 15, 2009


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