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The Journal of Heredity 2002:93(3)
© 2002 The American Genetic Association 93:227-228

Computer Note

MDM: A Program to Compute Fully Informative Genotype Frequencies in Complex Breeding Schemes

B. Servin, C. Dillmann, G. Decoux, and F. Hospital

From the Station de Géenéetique Véegéetale, INRA/UPS/INAPG, Ferme du Moulon, 91190 Gif sur Yvette, France.

Address correspondence to Bertrand Servin at the address above or e-mail: servin@moulon.inra.fr.

The first 10% of the full text of this article appears below.


   Introduction
 
In many genetics studies it is necessary to compute the expected frequencies of genotypes at marker loci and/or to infer the genotypes at chromosomal locations from the known genotypes at markers. This is the case, for example, for quantitative trait loci (QTL) detection, where likelihood ratio tests or multiple regressions are based on the probabilities of the different genotypes at a putative QTL location, given the genotypes at flanking markers. This is also the case for "graphical genotypes" (Young and Tanksley 1989), where it is wanted to estimate the genomic composition of the chromosomes (parental origin of the alleles) given the genotypes at markers.

The calculations performed by most existing programs (e.g., for QTL detection) are based solely on the genotypes at the two closest markers flanking the putative position on . . . [Full Text of this Article]


   Principle
 

   Running the Program
 

   Package
 

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