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The Journal of Heredity 2000:91(4)
© 2000 The American Genetic Association 91:343-345

Brief communication. Linkage mapping of the ovine {alpha}-inhibin (INHA), ßA-inhibin/activin (INHBA), and ßB-inhibin/activin (INHBB) genes

S Hiendleder, KG Dodds, and R Wassmuth

A full-sib mapping population was typed for Taql Southern blot RFLPs at the ovine {alpha}-inhibin (INHA), ßA-inhibin/activin (INHBA), and ßB=-inhibin/activin (INHBB) loci. The most likely positions were found by genetic linkage analysis. INHA was placed on ovine chromosome 2q, between microsatellite markers BM6444 and INRA 135, while INHBB was located 39 cM proximal to INHA between markers BMS1126 and BMS2626. The INHBA gene, a comparative mapping anchor locus, mapped to chromosome 4, between microsatellites OARCP26 and BMS719. These data confirm and refine previous chromosomal assignments by in situ hybridization, provide comparative mapping information, and identify microsatellite markers suitable for QTL association studies with inhibin/activin genes in ruminants.


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