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The Journal of Heredity 2002:93(1)
© 2002 The American Genetic Association 93:1-8

Genome Scan Reveals New Coat Color Loci in Exotic Pig Cross

H. Hirooka, D. J. de Koning, J. A. M. van Arendonk, B. Harlizius, P. N. de Groot, and H. Bovenhuis

From the Faculty of Economics, Ryukoku University, Fushimi-ku, Kyoto-shi, Kyoto, Japan (Hirooka), and Animal Breeding and Genetic Group, Wageningen Institute of Animal Sciences, Wageningen University, P.O. Box 338, 6700AH Wageningen, The Netherlands (de Koning, van Arendonk, Harlizius, de Groot, Bovenhuis). B. Harlizius is currently at the Institute for Pig Genetics BV (IPG), Beuningen, The Netherlands.

Address correspondence to Henk Bovenhuis at the address above or e-mail: Henk.Bovenhuis{at}alg.vf.wag-ur.nl.

The porcine genome was scanned to identify loci affecting coat color in an experimental cross between the Meishan breed and Dutch commercial lines. Linkage was studied in 1181 F2 animals for 132 microsatellite markers and seven binary coat color scores: White, Black spotting, Speckle, Gray, Black, and specific color phenotypes for head and legs. The analyses were performed using interval mapping under various models. The study confirmed the existence of coat color loci on chromosome 8 and chromosome 6. One additional locus affecting White was detected on chromosome 5, possibly representing the porcine equivalent of the steel factor. Two new loci affecting Black were detected on chromosome 2. One of these showed exclusive maternal expression and mapped to a region where imprinted genes have been reported. The effect of the binary coding was tested by additional analyses excluding the white animals (>50% of F2 animals). This showed that Black spotting was strongly influenced by the locus on chromosome 6 and the other color phenotypes were mainly influenced by the locus on chromosome 8. Epistatic effects were found between the loci on chromosomes 6 and 8 for Black spotting. For Black color, all combinations among chromosomes 2, 6, and 8 showed epistatic effects.


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