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Journal of Heredity Advance Access originally published online on December 23, 2004
Journal of Heredity 2005 96(2):85-88; doi:10.1093/jhered/esi017
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© The American Genetic Association. 2004. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

On the Estimation of Genome-wide Heterozygosity Using Molecular Markers

Y. D. DeWoody, and J. A. DeWoody

From the Department of Forestry and Natural Resources, Purdue University, West Lafayette, IN 47907–1159

Address correspondence to Andrew DeWoody at the address above, or e-mail: dewoody{at}purdue.edu.

Coltman and Slate (2003) recently performed a meta-analysis on studies that investigated the association between genetic variation at microsatellite loci and phenotypic trait variation. One factor not explicitly addressed in their meta-analysis is the actual estimation of genome-wide heterozygosity via molecular markers. Many authors still associate marker-estimated heterozygosity with genome-wide heterozygosity, despite allozyme-based evidence that such correlations are usually very weak or nonexistent. Here, we show that genome-wide heterozygosity is poorly estimated not only by allozymes but also by microsatellite loci and by single-nucleotide polymorphisms (SNPs). Thus, associations between fitness (or other phenotypes) and heterozygosity should be established firmly on causative factors and not on simple correlations.


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