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Journal of Heredity Advance Access originally published online on October 26, 2005
Journal of Heredity 2005 96(7):847-853; doi:10.1093/jhered/esi109
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© The American Genetic Association. 2005. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Analysis of Allele Fidelity, Polymorphic Information Content, and Density of Microsatellites in a Genome-Wide Screening for Hip Dysplasia in a Crossbreed Pedigree

R. G. Mateescu, Z. Zhang, K. Tsai, J. Phavaphutanon, N. I. Burton-Wurster, G. Lust, R. Quaas, K. Murphy, G. M. Acland, and R. J. Todhunter

From the Baker Institute for Animal Health (Mateescu, Burton-Wurster, Lust, and Acland) and the Department of Clinical Sciences (Todhunter), College of Veterinary Medicine, Cornell University, NY 14853; the Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, NY 14853 (Zhang, Quaas); the Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, TX 77845 (Tsai, Murphy); and the Department of Companion Animal, Faculty of Veterinary Medicine, Kasetsart University, Nakhon-Pathom 73140, Thailand (Phavaphutanon)

Address correspondence to Rory Todhunter, Box 32, College of Veterinary Medicine, Cornell University, Ithaca NY 14853, or e-mail: rjt2{at}cornell.edu.

Recent advances in genomics resources and tools are facilitating quantitative trait locus mapping. We developed a crossbreed pedigree for mapping quantitative trait loci for hip dysplasia in dogs by crossing dysplastic Labrador Retrievers and normal Greyhounds. We show that one advantage to using a crossbreed pedigree is the increased marker informativeness in the backcross/F2 population relative to the founder populations. We also discuss three factors that affect the detection power in the context of this crossbreed pedigree: being able to detect and correct genotyping errors, increasing marker density for chromosomes with a sparse coverage, and adding individuals to the mapping population as soon as they become available.


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