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Journal of Heredity Advance Access originally published online on January 11, 2006
Journal of Heredity 2006 97(1):74-80; doi:10.1093/jhered/esj004
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© The American Genetic Association. 2006. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Brief Communication

The Candidate Gene, Clock, Localizes to a Strong Spawning Time Quantitative Trait Locus Region in Rainbow Trout

E. H. Leder, R. G. Danzmann, and M. M. Ferguson

From the Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada N1G 2W1. E.H. Leder is now at the National Center for Cool and Cold Water Aquaculture, USDA-ARS, 1861 Leetown Road, Kearneysville, WV 25430

Address correspondence to E. H. Leder at the address above, or e-mail: eleder{at}ncccwa.ars.usda.gov.

We applied a candidate gene mapping approach to an existing quantitative trait loci (QTL) data set for spawning date in rainbow trout (Oncorynchus mykiss) to ascertain whether these genes could potentially account for any observed QTL effects. Several genes were chosen for their known or suspected roles in reproduction, circadian, or circannual timing, including salmon-type gonadotropin-releasing hormone 3A and 3B (GnRH3A and GnRH3B), Clock, Period1, and arylalkylamine N-acetlytransferase–1 and –2 (AANAT-1 and AANAT-2). Genes were sequenced, and polymorphisms were identified in parents of two rainbow trout mapping families, one of which was used previously to detect spawn timing QTL. Interval mapping was used to identify associations between genetic markers and spawning date effects. Using a genetic map that was updated with 574 genetic markers (775 total), we found evidence for 11 significant or suggestive QTL regions. Most QTL were only localized within one of the parents; however, a strong QTL region was identified in both female and male parents on linkage group RT-8 that explained 20% and 50% of trait variance, respectively. The Clock gene mapped to this region. Period1 mapped to a region in the female parent associated with a marginal effect (P = .056) on spawn timing. Other candidate genes were not associated with significant QTL effects.


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