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Journal of Heredity Advance Access originally published online on December 28, 2006
Journal of Heredity 2007 98(2):111-114; doi:10.1093/jhered/esl065
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© The American Genetic Association. 2006. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Symposium Articles

Localization and Characterization of X Chromosome Inversion Breakpoints Separating Drosophila mojavensis and Drosophila arizonae

Elizabeth T. Cirulli, and Mohamed A. F. Noor

From the University Program in Genetics and Genomics, Duke University, Durham, NC 27708 (Cirulli); and the Biology Department, Box 90338, Duke University, Durham, NC 27708 (Noor)

Address correspondence to M. A. F. Noor at the address above, or e-mail: noor{at}duke.edu.

Ectopic exchange between transposable elements or other repetitive sequences along a chromosome can produce chromosomal inversions. As a result, genome sequence studies typically find sequence similarity between corresponding inversion breakpoint regions. Here, we identify and investigate the breakpoint regions of the X chromosome inversion distinguishing Drosophila mojavensis and Drosophila arizonae. We localize one inversion breakpoint to 13.7 kb and localize the other to a 1-Mb interval. Using this localization and assuming microsynteny between Drosophila melanogaster and D. arizonae, we pinpoint likely positions of the inversion breakpoints to windows of less than 3000 bp. These breakpoints define the size of the inversion to approximately 11 Mb. However, in contrast to many other studies, we fail to find significant sequence similarity between the 2 breakpoint regions. The localization of these inversion breakpoints will facilitate future genetic and molecular evolutionary studies in this species group, an emerging model system for ecological genetics.

Corresponding Editor: Loren Rieseberg


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