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Journal of Heredity Advance Access originally published online on July 19, 2007
Journal of Heredity 2007 98(5):421-427; doi:10.1093/jhered/esm057
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© The American Genetic Association. 2007. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Association of Germ-line Polymorphisms in the Feline p53 Gene with Genetic Predisposition to Vaccine-Associated Feline Sarcoma

Nilanjana Banerji, Vivek Kapur, and Sagarika Kanjilal

From the Department of Medicine, University of Minnesota, St. Paul, MN 55108 (Banerji and Kanjilal); the Department of Microbiology, University of Minnesota, St. Paul, MN 55108 (Kapur); and the BioMedical Genomics Center (Kapur and Kanjilal), Cargill Building for Genomics, 1500 Gortner Avenue, University of Minnesota, St. Paul, MN 55108

Address correspondence to S. Kanjilal at the address above, or e-mail: kanjilal{at}umn.edu or kanjilal{at}psu.edu.

A case–control study was conducted in order to investigate the association of polymorphisms in the genomic sequence of the feline p53 gene with a predisposition to vaccine-associated feline sarcoma (VAFS). In the study, 50 domestic short hair cats with a confirmed histopathologic diagnosis of VAFS were matched to disease-free controls (1:2) by age, sex, and breed. Cats from both the diseased (case) and control groups were also negative for feline leukemia virus and feline immunodeficiency virus. Germ-line DNA was prepared from blood samples from cats in both groups and analyzed for sequence variation at 8 polymorphic sites in the p53 gene. A strong association was found between VAFS and the presence of specific nucleotides at 2 of the polymorphic sites. The strongest association was observed for a single-base insertion in intron 7 of the gene with an odds ratio of 8.99 (95% confidence interval = 3.42–23.57, P < 0.0001). The results of the study indicate that analysis of the presence or absence of the identified genetic markers in apparently healthy disease-free cats may help in predicting which individual animals are at greater risk of developing the disease.

This paper was delivered at the 3rd International Conference on the Advances in Canine and Feline Genomics, School of Veterinary Medicine, University of California, Davis, CA, August 3–5, 2006.

Corresponding Editor: Elaine Ostrander


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