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Journal of Heredity Advance Access originally published online on July 28, 2007
Journal of Heredity 2007 98(5):500-505; doi:10.1093/jhered/esm054
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© The American Genetic Association. 2007. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Functional Analysis of a Subset of Canine Olfactory Receptor Genes

Naima Benbernou, Sandrine Tacher, Stéphanie Robin, Michaelle Rakotomanga, Fabrice Senger, and Francis Galibert

From the Laboratory of Genetic and Development, CNRS UMR 6061, Institut de Génétique et Développement de Rennes, Faculté de Médecine, Rennes, F-35043 France (Benbernou, Tacher, Robin, Rakotomanga, Senger, and Galibert) Present address of F. Senger: UMR 6026, Faculté des sciences, Beaulieu, Rennes, France

Address correspondence to F. Galibert at the address above, or e-mail: francis.galibert{at}univ-rennes1.fr.

In this paper, we explored the level complexity of the combinatorial olfactory code that allows mammals with a repertoire of about thousand putatively active olfactory receptors encoded in their genomes to recognize and identify a much larger repertoire of odorant molecules. To that end, we cloned 38 canine OR genes belonging to the same OR gene family and transiently expressed them in a subclone of embryonic human kidney cells (HEK293) permanently expressing the G(olf) subunit. Using a Ca2+ imaging approach, we established for example that as many as 26 out of the 38 cloned OR elicited a Ca2+ response when exposed to octanal, whereas 10 responded to nonanal, other aldehydes providing intermediate responses. Altogether, these results demonstrated that the combinatorial code is quite complex in support to the highly developed sense of olfaction demonstrated by dogs.

Corresponding Editor: Elaine Ostrander

This paper was delivered at the 3rd International Conference on the Advances in Canine and Feline Genomics, School of Veterinary Medicine, University of California, Davis, CA, August 3–5, 2006.


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