Skip Navigation


Journal of Heredity Advance Access originally published online on September 1, 2007
Journal of Heredity 2007 98(6):555-566; doi:10.1093/jhered/esm072
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Supplementary Material
Right arrow All Versions of this Article:
98/6/555    most recent
esm072v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (2)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kehler, J. S.
Right arrow Articles by Menotti-Raymond, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kehler, J. S.
Right arrow Articles by Menotti-Raymond, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The American Genetic Association. 2007. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Four Independent Mutations in the Feline Fibroblast Growth Factor 5 Gene Determine the Long-Haired Phenotype in Domestic Cats

James S. Kehler, Victor A. David, Alejandro A. Schäffer, Kristina Bajema, Eduardo Eizirik, David K. Ryugo, Steven S. Hannah, Stephen J. O'Brien, and Marilyn Menotti-Raymond

From the Laboratory of Genomic Diversity, National Cancer Institute-Frederick, Frederick, MD 21702 (Kehler, David, Bajema, O'Brien, and Menotti-Raymond); Center for Animal Transgenesis and Germ Cell Research, Room 102, Myrin Building, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348 (Kehler); Department of Health and Human Services, National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD 20894 (Schäffer); Centro de Biologia Genômica e Molecular, Faculdade de Biociências, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS 90619-900, Brazil (Eizirik); Department of Otolaryngology and Neuroscience, 720 Rutland Avenue, Johns Hopkins University, Baltimore, MD 21205 (Ryugo); and Nestlé-Purina PetCare Company, St. Louis, MO 63134 (Hannah)

Address correspondence to J. S. Kehler at the address above, or e-mail: jkehler{at}ncifcrf.gov.

To determine the genetic regulation of "hair length" in the domestic cat, a whole-genome scan was performed in a multigenerational pedigree in which the "long-haired" phenotype was segregating. The 2 markers that demonstrated the greatest linkage to the long-haired trait (log of the odds ≥ 6) flanked an estimated 10-Mb region on cat chromosome B1 containing the Fibroblast Growth Factor 5 (FGF5) gene, a candidate gene implicated in regulating hair follicle growth cycle in other species. Sequence analyses of FGF5 in 26 cat breeds and 2 pedigrees of nonbreed cats revealed 4 separate mutations predicted to disrupt the biological activity of the FGF5 protein. Pedigree analyses demonstrated that different combinations of paired mutant FGF5 alleles segregated with the long-haired phenotype in an autosomal recessive manner. Association analyses of more than 380 genotyped breed and nonbreed cats were consistent with mutations in the FGF5 gene causing the long-haired phenotype in an autosomal recessive manner. In combination, these genomic approaches demonstrated that FGF5 is the major genetic determinant of hair length in the domestic cat.

Corresponding Editor: Leif Andersson

Received March 19, 2007
Accepted July 11, 2007


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Genome ResHome page
J. U. Pontius, J. C. Mullikin, D. R. Smith, Agencourt Sequencing Team, K. Lindblad-Toh, S. Gnerre, M. Clamp, J. Chang, R. Stephens, B. Neelam, et al.
Initial sequence and comparative analysis of the cat genome
Genome Res., November 1, 2007; 17(11): 1675 - 1689.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.