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Journal of Heredity Advance Access published online on December 23, 2004
Journal of Heredity, doi:10.1093/jhered/esi017
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© 2005 The American Genetic Association
Received June 1, 2004
Accepted August 15, 2004

Article

On the Estimation of Genome-wide Heterozygosity Using Molecular Markers

Y. D. DeWoody 1 and J. A. DeWoody 1*

1 From the Department of Forestry and Natural Resources, Purdue University, West Lafayette, IN 47907-1159

* To whom correspondence should be addressed.
J. A. DeWoody, E-mail: dewoody{at}purdue.edu


  Abstract

Coltman and Slate (2003) recently performed a meta-analysis on studies that investigated the association between genetic variation at microsatellite loci and phenotypic trait variation. One factor not explicitly addressed in their meta-analysis is the actual estimation of genome-wide heterozygosity via molecular markers. Many authors still associate marker-estimated heterozygosity with genome-wide heterozygosity, despite allozyme-based evidence that such correlations are usually very weak or nonexistent. Here, we show that genome-wide heterozygosity is poorly estimated not only by allozymes but also by microsatellite loci and by single-nucleotide polymorphisms (SNPs). Thus, associations between fitness (or other phenotypes) and heterozygosity should be established firmly on causative factors and not on simple correlations.


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