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Journal of Heredity Advance Access published online on January 13, 2005
Journal of Heredity, doi:10.1093/jhered/esi022
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© 2005 The American Genetic Association
Received March 30, 2004
Accepted August 20, 2004

Brief Communication

A Nucleotide Substitution Responsible for the Tawny Coat Color Mutation Carried by the MSKR Inbred Strain of Mice

A. Wada 1*, T. Kunieda 2, M. Nishimura 3, Y. Kakizoe-Ishida 4, N. Watanabe 5, K. Ohkawa 1, and M. Tsudzuki 6

1 From the Laboratory Animal Facility, Research Center for Medical Sciences, Jikei University School of Medicine, Tokyo, Japan
2 From the Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
3 From the Institute for Laboratory Animal Research, Graduate School of Medicine, Nagoya University, Aichi, Japan
4 From the Port of Nagoya Public Aquarium, Aichi, Japan
5 From the Department of Tropical Medicine, Jikei University School of Medicine, Tokyo, Japan
6 From the Laboratory of Animal Breeding and Genetics, Graduate School of Biosphere Science, Hiroshima University, Hiroshima, Japan

* To whom correspondence should be addressed.
A. Wada, E-mail: adumiw{at}jikei.ac.jp


  Abstract

"Tawny" is an autosomal recessive coat color mutation found in a wild population of Mus musculus molossinus. The inbred strain MSKR carries the mutation. The causative gene Mc1rtaw of the tawny phenotype is the second recessive allele at the melanocortin 1 receptor locus and is dominant to the first recessive allele, "recessive yellow" (Mc1re). The Mc1rtaw gene has six nucleotide substitutions, and its forecasted transcript has three amino acid substitutions (i.e., V101A, V216A, W252C). Though the nucleotide substitutions leading to V101A and V216A exist in various mouse strains, the nucleotide substitution leading to W252C exists in only tawny-colored mice. Thus this substitution is considered to be responsible for the expression of the tawny coat color. The frequency of the allele having this nucleotide substitution was 9.21% in the wild M. m. molossinus population inhabiting Sakai City, Osaka Prefecture, Japan, where the ancestral mice of the MSKR strain were captured.


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