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Journal of Heredity Advance Access published online on June 15, 2005
Journal of Heredity, doi:10.1093/jhered/esi079
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© The American Genetic Association. 2005. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org.

Article

Chromosomal Assignment of the Canine Melanophilin Gene (MLPH): A Candidate Gene for Coat Color Dilution in Pinschers

U. Philipp 1, P. Quignon 2, A. Scott 3, C. André 2, M. Breen 3, and T. Leeb 1*

1 From the Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bünteweg 17p, 30559 Hannover, Germany
2 UMR6061, CNRS, Université de Rennes1, 2 av. Pr. Léon Bernard, 35043 Rennes Cedex, France
3 College of Veterinary Medicine, 4700 Hillsborough Street, North Carolina State University, Raleigh, NC 27606

* To whom correspondence should be addressed.
T. Leeb, E-mail: tosso.leeb{at}tiho-hannover.de


  Abstract

Pinschers affected by coat color dilution show a specific pigmentation phenotype. The dilute pigmentation phenotype leads to a silver-blue appearance of the eumelanin-containing fur and a pale sandy color of pheomelanin-containing fur. In Pinscher breeding, dilute black-and-tan dogs are called "blue," and dilute red or brown animals are termed "fawn" or "Isabella fawn." Coat color dilution in Pinschers is sometimes accompanied by hair loss and a recurrent infection of the hair follicles. In human and mice, several well-characterized genes are responsible for similar pigment variations. To investigate the genetic cause of the coat color dilution in Pinschers, we isolated BAC clones containing the canine ortholog of the known murine color dilution gene Mlph. RH mapping of the canine MLPH gene was performed using an STS marker derived from BAC sequences. Additionally, one MLPH BAC clone was used as probe for FISH mapping, and the canine MLPH gene was assigned to CFA25q24.


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 J HeredHome page
M. Welle, U. Philipp, S. Rufenacht, P. Roosje, M. Scharfenstein, E. Schutz, B. Brenig, M. Linek, L. Mecklenburg, P. Grest, et al.
MLPH Genotype--Melanin Phenotype Correlation in Dilute Dogs
J. Hered., July 1, 2009; 100(suppl_1): S75 - S79.
[Abstract] [Full Text] [PDF]

Home page
 J HeredHome page
C. Drogemuller, U. Philipp, B. Haase, A.-R. Gunzel-apel, and T. Leeb
A Noncoding Melanophilin Gene (MLPH) SNP at the Splice Donor of Exon 1 Represents a Candidate Causal Mutation for Coat Color Dilution in Dogs
J. Hered., August 3, 2007; (2007) esm021v3.
[Abstract] [Full Text] [PDF]


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