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Journal of Heredity Advance Access published online on October 26, 2005
Journal of Heredity, doi:10.1093/jhered/esi109
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© The American Genetic Association. 2005. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Article

Analysis of Allele Fidelity, Polymorphic Information Content, and Density of Microsatellites in a Genome-Wide Screening for Hip Dysplasia in a Crossbreed Pedigree

R. G. Mateescu 1, Z. Zhang 2, K. Tsai 3, J. Phavaphutanon 4, N. I. Burton-Wurster 1, G. Lust 1, R. Quaas 2, K. Murphy 3, G. M. Acland 1, and R. J. Todhunter 5*

1 From the Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, NY 14853
2 From the Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, NY 14853
3 From the Department of Veterinary Pathobiology, College of Veterinary Medicine, Texas A&M University, TX 77845
4 From the Department of Companion Animal, Faculty of Veterinary Medicine, Kasetsart University, Nakhon-Pathom 73140, Thailand
5 From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, NY 14853

* To whom correspondence should be addressed.
R. J. Todhunter, E-mail: rjt2{at}cornell.edu


  Abstract

Recent advances in genomics resources and tools are facilitating quantitative trait locus mapping. We developed a crossbreed pedigree for mapping quantitative trait loci for hip dysplasia in dogs by crossing dysplastic Labrador Retrievers and normal Greyhounds. We show that one advantage to using a crossbreed pedigree is the increased marker informativeness in the backcross/F2 population relative to the founder populations. We also discuss three factors that affect the detection power in the context of this crossbreed pedigree: being able to detect and correct genotyping errors, increasing marker density for chromosomes with a sparse coverage, and adding individuals to the mapping population as soon as they become available.


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