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Journal of Heredity Advance Access published online on November 2, 2005
Journal of Heredity, doi:10.1093/jhered/esi114
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© The American Genetic Association. 2005. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.
Received May 17, 2005
Accepted September 21, 2005

Article

High Diversity of the Chicken Growth Hormone Gene and Effects on Growth and Carcass Traits

Q. Nie 1, B. Sun 1, D. Zhang 1, C. Luo 1, N. A. Ishag 1, M. Lei 1, G. Yang 1, and X. Zhang 1*

1 From the Department of Animal Genetics, Breeding and Reproduction, College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong, China

* To whom correspondence should be addressed.
X. Zhang, E-mail: xqzhang{at}scau.edu.cn


  Abstract

The chicken growth hormone (cGH) gene plays a crucial role in controlling growth and metabolism, leading to potential correlations between cGH polymorphisms and economic traits. In this study, DNA from four divergent chicken breeds were screened for single nucleotide polymorphisms (SNPs) in the cGH gene using denaturing high-performance liquid chromatography and sequencing. A total of 46 SNPs were identified, of which 4 were in the 5' untranslated region, 1 in the 3' untranslated region, 5 in exons (two of which are nonsynonymous), with the remaining 36 in introns. The nucleotide diversity in the cGH gene ({theta} = 2.7 x 10-3) was higher than that reported for other chicken genes, even within the same breeds. The associations of five of these SNPs and their haplotypes with chicken growth and carcass traits were determined using polymerase chain reaction-restriction fragment length polymorphism analysis in a F2 resource population cross of two of the four chicken breeds (White Recessive Rock and Xinghua). This analysis shows that, among other correlations, G+1705A was significantly associated with body weight at all ages measured, shank length at three of four ages measured, and average daily gain within weeks 0 to 4. Thus, this cGH polymorphism, or another polymorphism that is in linkage disequilibrium with G+1705A, appears to correspond to a significant growth-related quantitative trait locus difference between the two breeds used to construct the resource population.


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[Abstract] [Full Text] [PDF]


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