Skip Navigation



Journal of Heredity Advance Access published online on October 26, 2005
Journal of Heredity, doi:10.1093/jhered/esi121
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
96/7/764    most recent
esi121v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Richter, A.
Right arrow Articles by Bullerdiek, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Richter, A.
Right arrow Articles by Bullerdiek, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The American Genetic Association. 2005. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Article

RAS Gene Hot-Spot Mutations in Canine Neoplasias

A. Richter 1, H. Murua Escobar 2, K. Günther 1, J. T. Soller 1, S. Winkler 1, I. Nolte 3, and J. Bullerdiek 1*

1 From the Centre for Human Genetics, University of Bremen, Leobener Strasse ZHG, 28359 Bremen, Germany
2 From the Centre for Human Genetics, University of Bremen, Leobener Strasse ZHG, 28359 Bremen, Germany; From the Small Animal Clinic, School of Veterinary Medicine, Bischofsholer Damm 15, 30173 Hanover, Germany
3 From the Small Animal Clinic, School of Veterinary Medicine, Bischofsholer Damm 15, 30173 Hanover, Germany

* To whom correspondence should be addressed.
J. Bullerdiek, E-mail: bullerd{at}uni-bremen.de


  Abstract

Point mutations in the cellular homologues HRAS, KRAS2, and NRAS of the viral Harvey and Kirsten rat sarcoma virus oncogenes are commonly involved in the onset of malignancies in humans and other species such as dog, mouse, and rat. Most often, three particular hot-spot codons are affected, with one amino acid exchange being sufficient for the induction of tumor growth. While RAS genes have been shown to play an important role in canine tumors such as non-small lung cell carcinomas, data about RAS mutations in canine fibrosarcomas as well as KRAS2 mutations in canine melanomas is sparse. To increase the number of tumors examined, we recently screened 13 canine fibrosarcomas and 11 canine melanomas for point mutations, particularly within the mutational hot spots. The results were compared to the already existing data from other studies about these tumors in dogs.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.