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Journal of Heredity Advance Access published online on November 2, 2005
Journal of Heredity, doi:10.1093/jhered/esi128
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© The American Genetic Association. 2005. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.
Received April 11, 2005
Accepted August 29, 2005

Article

Complex Segregation Analysis of Canine Hip Dysplasia in German Shepherd Dogs

V. Janutta 1, H. Hamann 1, and O. Distl 1*

1 From the Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Foundation, Bünteweg 17p, 30559 Hannover, Germany

* To whom correspondence should be addressed.
O. Distl, E-mail: ottmar.distl{at}tiho-hannover.de


  Abstract

Complex segregation analyses were carried out to clarify the mode of inheritance of canine hip dysplasia (CHD) in German shepherd dogs. Data were used from 8,567 animals examined for CHD from 20 families with three to four generations. The existence of a major gene in addition to polygenic gene effects was detected. In the present study, a mixed model with a dominant major gene effect seemed to be most probable for dichotomous encoding (0: dogs without signs of CHD; 1: dogs with borderline/slight to severe CHD). In addition, mixed major gene inheritance was shown for a binary trait where borderline was assigned to dogs scored free from CHD and for a trichotomously encoded trait (0: dogs without signs of CHD; 1: borderline CHD; 2: mild to severe CHD). Although only small frequencies were found for the unfavorable homozygotic genotype AA, the probability of the AB genotype was high in affected animals. Selection schemes to reduce the frequency of the allele A should therefore efficiently improve existing breeding programmes in German shepherd dogs.


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[Abstract] [Full Text] [PDF]


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