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Journal of Heredity Advance Access published online on January 4, 2006
Journal of Heredity, doi:10.1093/jhered/esj002
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© The American Genetic Association. 2005. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.
Received September 20, 2004
Accepted October 13, 2005

Brief Communication

An Algorithm for Analyzing Linkages Affected by Heterozygous Translocations: QuadMap

J. D. Durrant 1, B. W. Gardunia 2, K. D. Livingstone 3, M. R. Stevens 1, and E. N. Jellen 1 *

1 From the Department of Plant and Animal Sciences, 275 WIDB, Brigham Young University, Provo, UT 84602
2 From the Department of Crop and Soil Sciences, New Beasley Lab, Texas A&M University, College Station, TX 77802
3 From the Department of Biology, Trinity University, San Antonio, TX 78212

* To whom correspondence should be addressed.
E. N. Jellen, E-mail: rick_jellen{at}byu.edu


  Abstract

Heterozygous chromosome rearrangements such as reciprocal translocations are most accurately displayed as two-dimensional linkage maps. Standard linkage mapping software packages, such as MapMaker, generate only one-dimensional maps and so reciprocal translocations appear as clusters of markers, even though they originate from two nonhomologous chromosomes. To more accurately map these regions, researchers have developed statistical methods that use the variance in map distance to distinguish among the four segments (two translocation, two interstitial) of the translocation. In this study, we describe modifications to one of these protocols, that proposed by Livingstone et al. (2000). We also introduce QuadMap, a new software application for dissecting heterozygous translocation-affected linkage maps.


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