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Journal of Heredity Advance Access published online on February 17, 2006
Journal of Heredity, doi:10.1093/jhered/esj022
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© The American Genetic Association. 2006. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.
Received December 5, 2005
Accepted January 9, 2006

Brief Communication

Primate MicroRNAs miR-220 and miR-492 Lie within Processed Pseudogenes

Eric J. Devor 1 *

1 From Molecular Genetics and Bioinformatics, Integrated DNA Technologies, 1710 Commercial Park, Coralville, IA 52241

* To whom correspondence should be addressed.
Eric J. Devor, E-mail: rdevor{at}idtdna.com


  Abstract

MicroRNAs (miRNAs) are a new and abundant class of small, noncoding RNAs. To date, the evolutionary history of most of these loci appears to be marked by duplication and divergence. The ultimate origin of miRNAs remains an open question. A survey of the genomic context of more than 300 human miRNA loci revealed that two primate-specific miRNAs, miR-220 and miR-492, each lie within a processed pseudogene. In silico and in vitro examinations of these two loci suggest that this is a rare phenomenon requiring the juxtaposition of a specific combination of factors. Thus it appears that, while processed pseudogenes are good candidates for miRNA incubators, it is unlikely that more than a very small percentage of new miRNAs arise this way.


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