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Journal of Heredity Advance Access published online on April 19, 2006
Journal of Heredity, doi:10.1093/jhered/esj026
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© The American Genetic Association. 2006. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.
Received January 30, 2006
Accepted February 21, 2006

Brief Communication

SNP Identification and Analysis in Part of Intron 2 of Goat MSTN Gene and Variation within and among Species

Xiang-Long Li 1 *, Zhao-Long Wu 2, Zheng-Zhu Liu 3, Yuan-Fang Gong 3, Rong-Yan Zhou 1, and Gui-Ru Zheng 1

1 From the College of Animal Science and Technology, Hebei Agricultural University, No. 289 Lingyusi Street, Baoding 071001, Hebei Province, China
2 From the School of Medicine, Jishou University, Jishou 416000, China
3 From the Department of Animal Science, Hebei Normal University of Science & Technology, Changli 066600, China

* To whom correspondence should be addressed.
Xiang-Long Li, E-mail: lixianglongcn{at}yahoo.com


  Abstract

Part of intron 2 of the myostatin (MSTN) gene of 140 goats from 24 populations and 38 sheep from 8 breeds were sequenced, and similar sequences of different species from Gene bank were also obtained to study MSTN diversity within and among species. The results indicated that there were seven polymorphic sites in the sequenced region of goat, which have not been separated by recombination (or recurrent mutation), presented complete linkage disequilibrium, and could be sorted into three haplotypes. There was no polymorphic site in the sequenced region of sheep. The haplotype diversity, nucleotide diversity, and average number of single nucleotide polymorphism (SNP) differences of goats from the South group are higher than those of North group, and the corresponding value of the Foreign group is also higher than that of Chinese. The genetic differentiation (0.7558) between the Foreign and Chinese group is significant. There are two main haplotypes of the MSTN intron 2 in the goat, which may represent two ancestral types, in support of the theory that domestic goats in the world mainly originated from two ancestors based on morphology, history, archaeology, and molecular markers. The sequence differences of the MSTN intron 2 among species are greater than those within species.


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