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Journal of Heredity Advance Access published online on June 22, 2006
Journal of Heredity, doi:10.1093/jhered/esl009
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© The American Genetic Association. 2006. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.
Received June 12, 2005
Accepted March 20, 2006

Article

A Quantitative Trait Locus Analysis of Natural Genetic Variation for Drosophila melanogaster Oxidative Stress Survival

Yue Wang 1, David Pot 2, Stephen D. Kachman 1, Sergey V. Nuzhdin 3, and Lawrence G. Harshman 4 *

1 From the Department of Statistics, University of Nebraska-Lincoln, Lincoln, NE 68583-0963
2 CIRAD, UMR PIA 1096, Avenue Agropolis, 34398 Montpellier Cedex 5, France
3 From the Section of Evolution and Ecology, University of California at Davis, Davis, CA 95616
4 From the School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE 68588-0118

* To whom correspondence should be addressed.
Lawrence G. Harshman, E-mail: lharsh{at}unlserve.unl.edu


  Abstract

Little is known about natural genetic variation for survival under oxidative stress conditions or whether genetic variation for oxidative stress survival is associated with that for life-history traits. We have investigated survival in a high-oxygen environment at 2 adult densities using a set of recombinant inbred lines (RILs) isolated from a natural population of Drosophila melanogaster. Female and male oxidative stress survival was highly correlated. Quantitative trait loci (QTLs) for oxidative stress survival were identified on both autosomes. These QTLs were sometimes sex or density specific but were most often not. QTLs were identified that colocalize to the same region of the genome as longevity in other studies using the same set of RILs. We also determined early-age egg production and found QTLs for this trait, but there was no support for an association between oxidative stress survival and egg production.


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