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Journal of Heredity Advance Access published online on April 8, 2007
Journal of Heredity, doi:10.1093/jhered/esm013
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© The American Genetic Association. 2007. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Cytochrome b Pseudogene Originated from a Highly Divergent Mitochondrial Lineage in Genus Rupicapra

Fernando Rodríguez, Jesús Albornoz, and Ana Domínguez

From the Departamento de Biología Funcional, Área de Genética, Universidad de Oviedo, 33071 Oviedo, Spain

Address correspondence to A. Domínguez at the address above, or e-mail: sanjurjo{at}uniovi.es.

We have identified a nuclear pseudogene (numt) of cytochrome b (cytb) in chamois. The comparison of a fragment of 402 nucleotides of cytb and the pseudogene between the 2 species Rupicapra rupicapra and Rupicapra pyrenaica allowed direct measurement of relative rates and patterns of evolution. Mitochondrial genes evolved 7 to 12 times faster than their nuclear counterparts. Substitutions in the nucleus include a frameshift and a stop codon. Phylogenetic analysis of nuclear and mitochondrial lineages on Rupicapra and related species showed that the nuclear branch evolved as a functional mitochondrial gene until the split of the 2 species of chamois and as a typical pseudogene later on. We propose that the pseudogene originated from a highly divergent mitochondrial lineage that did not persist in the mitochondrion and transposed to the nucleus in a time close to speciation. The concurrence of highly differentiated lineages at speciation points to hybridization between highly divergent populations.

Corresponding Editor: Stephen J. O'Brien

Received May 1, 2006
Accepted December 5, 2006


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F. Rodriguez, S. Hammer, T. Perez, F. Suchentrunk, R. Lorenzini, J. Michallet, N. Martinkova, J. Albornoz, and A. Dominguez
Cytochrome b Phylogeography of Chamois (Rupicapra spp.). Population Contractions, Expansions and Hybridizations Governed the Diversification of the Genus
J. Hered., January 1, 2009; 100(1): 47 - 55.
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