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Journal of Heredity Advance Access published online on August 28, 2007
Journal of Heredity, doi:10.1093/jhered/esm073
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© The American Genetic Association. 2007. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Book Review

The Origins of Genome Architecture

The Origins of Genome Architecture
Michael Lynch
Sinauer Associates, Inc. Publishers. Sunderland, MA. 2007. Hardcover,494 494 pp. $59.95. ISBN 978-0-87893-484-3.

The first 10% of the full text of this article appears below.

In the mid-nineteenth century, Charles Darwin was the first to identify natural selection as the mechanism of adaptive evolution. Although his observations described how the population evolves, there was no accurate model describing the mechanisms responsible for the origin of variation and its inheritance. In late 1960s and early 1970s, Kimura (1986) proposed the neutral theory of molecular evolution that attributed an important role to the genetic drift of neutral mutations. The debate between 2 theories is summarized by words of Lewin (1996):

To selectionists (natural selection) most mutations are either beneficial or harmful; beneficial ones are retained in the population, creating extensive variation, while harmful ones are removed. To neutralists (neutral theory), most mutations are adaptively neutral, and therefore become fixed in the population because . . . [Full Text of this Article]

Hussein Abdel-Haleem

Center of Applied Genetic Technologies, University of Georgia, 111 Riverbend Road, Athens, GA 30605

e-mail: hussein@uga.edu


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