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Journal of Heredity Advance Access published online on December 28, 2007
Journal of Heredity, doi:10.1093/jhered/esm101
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© The American Genetic Association. 2007. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Brief Communications

Characterization of Bovine TGM1 and Exclusion as Candidate Gene for Ichthyosis in Chianina

Sabrina Dardano, Barbara Gandolfi, Pietro Parma, Michele Polli, Barbara Bighignoli, Maria G. Strillacci, Maria C. Cozzi, Luciano Molteni, and Maria Longeri

From the Dipartimento di Scienze Animali, Sezione di Zootecnica Veterinaria, Università degli Studi di Milano, 20133 Milano, Italy (Dardano, Gandolfi, Polli, Bighignoli, Strillacci, Cozzi, and Longeri); and the Dipartimento di Scienze Animali, Sezione di Zootecnia Agraria, Università degli studi di Milano, 20133 Milano, Italy (Parma and Molteni)

Address correspondence to M. Longeri at the address above, or e-mail: maria.longeri{at}unimi.it.

Ichthyosis is a heterogeneous group of keratinization disorders reported both in human and animals. Two rare, inherited forms have been reported in cattle, both characterized by autosomal recessive transmission. Because mutations of transglutaminase 1 (TGM1) gene are associated with autosomal recessive ichthyosis in people, this gene was investigated as a candidate for the diseases in cattle. Three different polymorphisms were identified in 5' end region of cattle TGM1. Marker homozygosity was not found among affected calves. Linkage analysis excluded (logarithmic odds [LOD] score –2.0) TGM1 as the cause for ichthyosis phenotype in the analyzed Chianina cases.

Corresponding Editor: Ernest Bailey

Received June 14, 2007
Accepted October 7, 2007


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